Ibars, E., Codina-Fabra, J., Bellí, G., Casas, C., Tarrés, M., Solé-Soler, R., Lorite, N.P., Ximénez-Embún, P., Muñoz, J., Colomina, N., Torres-Rosell, J., 2023. Ubiquitin proteomics identifies RNA polymerase I as a target of the Smc5/6 complex. Cell Rep. 42, 112463.
Mellid, S., García, F., Leandro-García, L.J., Díaz-Talavera, A., Martínez-Montes, Á.M., Gil, E., Calsina, B., Monteagudo, M., Letón, R., Roldán-Romero, J.M., Santos, M., Lanillos, J., Valdivia, C., Martínez-Puente, N., de Nicolás-Hernández, J., Jiménez, S., Pérez-Martínez, M., Honrado, E., Coloma, J., Cerezo, A., Santiveri, C.M., Esteller, M., Campos-Olivas, R., Caleiras, E., Montero-Conde, C., Rodríguez-Antona, C., Muñoz, J., Robledo, M., Cascón, A., 2023. DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation and metabolic remodeling. Cancer Commun. 2–7.
Peinado-Izaguerri, J., Zarzuela, E., McLaughlin, M., Small, A.C., Riva, F., McKeegan, D.E.F., Bain, M., Muñoz, J., Bhide, M., Preston, T., 2023. A novel dynamic proteomics approach for the measurement of broiler chicken protein fractional synthesis rate. Rapid Commun. Mass Spectrom. 37, e9497.
Xia, Q., Casas-Martinez, J.C., Zarzuela, E., Muñoz, J., Miranda-Vizuete, A., Goljanek-Whysall, K., McDonagh, B., 2023. Peroxiredoxin 2 is required for the redox mediated adaptation to exercise. Redox Biol. 60, 102631.
Sanz-Castillo, B., Hurtado, B., Vara-Ciruelos, D., El Bakkali, A., Hermida, D., Salvador-Barbero, B., Martínez-Alonso, D., González-Martínez, J., Santiveri, C., Campos-Olivas, R., Ximénez-Embún, P., Muñoz, J., Álvarez-Fernández, M., Malumbres, M., 2023. The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner. EMBO J. 42, e110833.
Villarroya‐Beltri, C., Martins, A.F.B., García, A., Giménez, D., Zarzuela, E., Novo, M., del Álamo, C., González‐Martínez, J., Bonel‐Pérez, G.C., Díaz, I., Guillamot, M., Chiesa, M., Losada, A., Graña‐Castro, O., Rovira, M., Muñoz, J., Salazar‐Roa, M., Malumbres, M., 2023. Mammalian CDC14 phosphatases control exit from stemness in pluripotent cells . EMBO J. 42, e111251.
Elía, A., Saldain, L., Vanzulli, S.I., Helguero, L.A., Lamb, C.A., Fabris, V., Pataccini, G., Martínez-Vazquez, P., Burruchaga, J., Caillet-Bois, I., Spengler, E., Acosta Haab, G., Liguori, M., Castets, A., Lovisi, S., Abascal, M.F., Novaro, V., Sánchez, J., Muñoz, J., Belizán, J.M., Abba, M.C., Gass, H., Rojas, P., Lanari, C., 2023. Beneficial Effects of Mifepristone Treatment in Patients with Breast Cancer Selected by the Progesterone Receptor Isoform Ratio: Results from the MIPRA Trial. Clin. Cancer Res. 29, 866–877.
Marin, I., Boix, O., Garcia-Garijo, A., Sirois, I., Caballe, A., Zarzuela, E., Ruano, I., Attolini, C.S.-O., Prats, N., López-Domínguez, J.A., Kovatcheva, M., Garralda, E., Muñoz, J., Caron, E., Abad, M., Gros, A., Pietrocola, F., Serrano, M., 2023. Cellular Senescence Is Immunogenic and Promotes Antitumor Immunity. Cancer Discov. 13, 410–431.
Sayago, C., Sánchez-Wandelmer, J., García, F., Hurtado, B., Lafarga, V., Prieto, P., Zarzuela, E., Ximénez-Embún, P., Ortega, S., Megías, D., Fernández-Capetillo, O., Malumbres, M., Munoz, J., 2023. Decoding protein methylation function with thermal stability analysis. Nat. Commun. 14, 3016.
Cobo, I., Paliwal, S., Bodas, C., Felipe, I., Melià-Alomà, J., Torres, A., Martínez-Villarreal, J., Malumbres, M., García, F., Millán, I., del Pozo, N., Park, J.C., MacDonald, R.J., Muñoz, J., Méndez, R., Real, F.X., 2023. NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation. Nat. Commun. 14.
Molina‐Jiménez, F., Ugalde‐Triviño, L., Arias‐González, L., Relaño‐Rupérez, C., Casabona, S., Pérez‐Fernández, M.T., Martín‐Domínguez, V., Fernández‐Pacheco, J., Laserna‐Mendieta, E.J., Muñoz‐Hernández, P., Arias‐Arias, Á., Cano, A., Muñoz, J., Lucendo, A.J., Santander, C., Majano, P., 2023. Proteomic analysis of the esophageal epithelium reveals key features of eosinophilic esophagitis pathophysiology. Allergy 1–13
2022
Boix, O., Martinez, M., Vidal, S., Giménez-Alejandre, M., Palenzuela, L., Lorenzo-Sanz, L., Quevedo, L., Moscoso, O., Ruiz-Orera, J., Ximénez-Embún, P., Ciriaco, N., Nuciforo, P., Stephan-Otto Attolini, C., Albà, M.M., Muñoz, J., Tian, T. V., Varela, I., Vivancos, A., Ramón y Cajal, S., Muñoz, P., Rivas, C., Abad, M., 2022. pTINCR microprotein promotes epithelial differentiation and suppresses tumor growth through CDC42 SUMOylation and activation. Nat. Commun. 13, 6840.
Mouron, S., Bueno, M.J., Lluch, A., Manso, L., Calvo, I., Cortes, J., Garcia-Saenz, J.A., Gil-Gil, M., Martinez-Janez, N., Apala, J. V., Caleiras, E., Ximénez-Embún, P., Muñoz, J., Gonzalez-Cortijo, L., Murillo, R., Sánchez-Bayona, R., Cejalvo, J.M., Gómez-López, G., Fustero-Torre, C., Sabroso-Lasa, S., Malats, N., Martinez, M., Moreno, A., Megias, D., Malumbres, M., Colomer, R., Quintela-Fandino, M., 2022. Phosphoproteomic analysis of neoadjuvant breast cancer suggests that increased sensitivity to paclitaxel is driven by CDK4 and filamin A. Nat. Commun. 13, 7529.
Benito-Martin, A., Nogués, L., Hergueta-Redondo, M., Castellano-Sanz, E., Garvin, E., Cioffi, M., Sola-Castrillo, P., Buehring, W., Ximénez-Embún, P., Muñoz, J., Matei, I., Villanueva, J., Peinado, H., 2022. Mast cells impair melanoma cell homing and metastasis by inhibiting HMGA1 secretion. Immunology.
Rovira, M., Sereda, R., Pladevall-Morera, D., Ramponi, V., Marin, I., Maus, M., Madrigal-Matute, J., Díaz, A., García, F., Muñoz, J., Cuervo, A.M., Serrano, M., 2022. The lysosomal proteome of senescent cells contributes to the senescence secretome. Aging Cell 21, e13707.
García-Alonso, S., Mesa, P., Ovejero, L. de la P., Aizpurua, G., Lechuga, C.G., Zarzuela, E., Santiveri, C.M., Sanclemente, M., Muñoz, J., Musteanu, M., Campos-Olivas, R., Martínez-Torrecuadrada, J., Barbacid, M., Montoya, G., 2022. Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation. Mol. Cell 82, 3438-3452.e8.
Kuo, S.H., Tasset, I., Cheng, M.M., Diaz, A., Pan, M.K., Lieberman, O.J., Hutten, S.J., Alcalay, R.N., Kim, S., Ximénez-Embún, P., Fan, L., Kim, D., Ko, H.S., Yacoubian, T., Kanter, E., Liu, L., Tang, G., Muñoz, J., Sardi, S.P., Li, A., Gan, L., Cuervo, A.M., Sulzer, D., 2022. Mutant glucocerebrosidase impairs α-synuclein degradation by blockade of chaperone-mediated autophagy. Sci. Adv. 8.
Colomé, N., Abian, J., Aloria, K., Arizmendi, J.M., Barceló-Batllori, S., Braga-Lagache, S., Burlet-Schiltz, O., Carrascal, M., Casal, J.I., Chicano-Gálvez, E., Chiva, C., Clemente, L.F., Elortza, F., Estanyol, J.M., Fernandez-Irigoyen, J., Fernández-Puente, P., Fidalgo, M.J., Froment, C., Fuentes, M., Fuentes-Almagro, C., Gay, M., Hainard, A., Heller, M., Hernández, M.L., Ibarrola, N., Iloro, I., Kieselbach, T., Lario, A., Locard-Paulet, M., Marina-Ramírez, A., Martín, L., Morato-López, E., Muñoz, J., Navajas, R., Odena, M.A., Odriozola, L., de Oliveira, E., Paradela, A., Pasquarello, C., de los Rios, V., Ruiz-Romero, C., Sabidó, E., Sánchez del Pino, M., Sancho, J., Santamaría, E., Schaeffer-Reiss, C., Schneider, J., de la Torre, C., Valero, M.L., Vilaseca, M., Wu, S., Wu, L., Ximénez de Embún, P., Canals, F., Corrales, F.J., 2022. Multi-laboratory experiment PME11 for the standardization of phosphoproteome analysis. J. Proteomics 251, 1–6.
Zhu, L., Retana, D., García‐Gómez, P., Álvaro‐Espinosa, L., Priego, N., Masmudi‐Martín, M., Yebra, N., Miarka, L., Hernández‐Encinas, E., Blanco‐Aparicio, C., Martínez, S., Sobrino, C., Ajenjo, N., Artiga, M., Ortega‐Paino, E., Torres‐Ruiz, R., Rodríguez‐Perales, S., Soffietti, R., Bertero, L., Cassoni, P., Weiss, T., Muñoz, J., Sepúlveda, J.M., González‐León, P., Jiménez‐Roldán, L., Moreno, L.M., Esteban, O., Pérez‐Núñez, Á., Hernández‐Laín, A., Toldos, O., Ruano, Y., Alcázar, L., Blasco, G., Fernández‐Alén, J., Caleiras, E., Lafarga, M., Megías, D., Graña‐Castro, O., Nör, C., Taylor, M.D., Young, L.S., Varešlija, D., Cosgrove, N., Couch, F.J., Cussó, L., Desco, M., Mouron, S., Quintela‐Fandino, M., Weller, M., Pastor, J., Valiente, M., de la Lama‐Zaragoza, A., Calero‐Felix, L., Fiaño‐Valverde, C., Delgado‐López, P.D., Montalvo‐Afonso, A., Pascual‐Llorente, M., Díaz‐Piqueras, Á., Nam‐Cha, S., Barrena López, C., Plans Ahicart, G., Martínez‐Saez, E., Ramón y Cajal, S., Nicolás, P., 2022. A clinically compatible drug‐screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis. EMBO Mol. Med. 14, 1–29.
Peinado, P., Andrades, A., Cuadros, M., Rodriguez, M.I., Coira, I.F., Garcia, D.J., Benitez-Cantos, M.S., Cano, C., Zarzuela, E., Muñoz, J., Loidi, C., Saiz, M., Medina, P.P., 2022. Multi-omic alterations of the SWI/SNF complex define a clinical åsubgroup in lung adenocarcinoma. Clin. Epigenetics 14, 1–7.
Morales-Sanfrutos, J., Munoz, J., 2022. Unraveling the complexity of the extracellular vesicle landscape with advanced proteomics. Expert Rev. Proteomics 19, 89–101.
Serna, M., González-Corpas, A., Cabezudo, S., López-Perrote, A., Degliesposti, G., Zarzuela, E., Skehel, J.M., Muñoz, J., Llorca, O., 2022. CryoEM of RUVBL1-RUVBL2-ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8. Nucleic Acids Res. 50, 1128–1146.
Garrido, A., Kim, E., Teijeiro, A., Sánchez Sánchez, P., Gallo, R., Nair, A., Matamala Montoya, M., Perna, C., Vicent, G.P., Muñoz, J., Campos-Olivas, R., Melms, J.C., Izar, B., Schwabe, R.F., Djouder, N., 2022. Histone acetylation of bile acid transporter genes plays a critical role in cirrhosis. J. Hepatol. 76, 850–861.
Santos-Coquillat, A., González, M.I., Clemente-Moragón, A., González-Arjona, M., Albaladejo-García, V., Peinado, H., Muñoz, J., Ximénez Embún, P., Ibañez, B., Oliver, E., Desco, M., Salinas, B., 2022. Goat Milk Exosomes As Natural Nanoparticles for Detecting Inflammatory Processes By Optical Imaging. Small 18, 2105421.
Seidlitz, T., Schmäche, T., Garcίa, F., Lee, J.H., Qin, N., Kochall, S., Fohgrub, J., Pauck, D., Rothe, A., Koo, B., Weitz, J., Remke, M., Muñoz, J*., Stange, D.E*., 2022. Sensitivity towards HDAC inhibition is associated with RTK / MAPK pathway activation in gastric cancer . EMBO Mol. Med. 49, 1–16. * co-corresponding authors
2021
Juste, Y.R., Kaushik, S., Bourdenx, M., Aflakpui, R., Bandyopadhyay, S., Garcia, F., Diaz, A., Lindenau, K., Tu, V., Krause, G.J., Jafari, M., Singh, R., Muñoz, J., Macian, F., Cuervo, A.M., 2021. Reciprocal regulation of chaperone-mediated autophagy and the circadian clock. Nat. Cell Biol. 23, 1255–1270.
Galarreta, A., Valledor, P., Ubieto‐Capella, P., Lafarga, V., Zarzuela, E., Muñoz, J., Malumbres, M., Lecona, E., Fernandez‐Capetillo, O., 2021. USP7 limits CDK1 activity throughout the cell cycle. EMBO J. 40, e99692.
Lafarga, V., Sirozh, O., Díaz‐López, I., Galarreta, A., Hisaoka, M., Zarzuela, E., Boskovic, J., Jovanovic, B., Fernandez‐Leiro, R., Muñoz, J., Stoecklin, G., Ventoso, I., Fernandez‐Capetillo, O., 2021. Widespread displacement of DNA‐ and RNA‐binding factors underlies toxicity of arginine‐rich cell‐penetrating peptides. EMBO J. 40, 1–16.
González‐Acosta, D., Blanco‐Romero, E., Ubieto‐Capella, P., Mutreja, K., Míguez, S., Llanos, S., García, F., Muñoz, J., Blanco, L., Lopes, M., Méndez, J., 2021. PrimPol‐mediated repriming facilitates replication traverse of DNA interstrand crosslinks. EMBO J. 40, e106355.
Ramirez, J., Prieto, G., Olazabal-Herrero, A., Borràs, E., Fernandez-Vigo, E., Alduntzin, U., Osinalde, N., Beaskoetxea, J., Lectez, B., Aloria, K., Rodriguez, J.A., Paradela, A., Sabidó, E., Muñoz, J., Corrales, F., Arizmendi, J.M., Mayor, U., 2021. A proteomic approach for systematic mapping of substrates of human deubiquitinating enzymes. Int. J. Mol. Sci. 22, 4851.
García-Silva, S., Ximénez-Embún, P., Muñoz, J., Peinado, H., 2021. Postlymphadenectomy Analysis of Exosomes from Lymphatic Exudate/Exudative Seroma of Melanoma Patients. Methods Mol. Biol. 2265, 345–359.
Salmón, M., Paniagua, G., Lechuga, C.G., Fernández-García, F., Zarzuela, E., Álvarez-Díaz, R., Musteanu, M., Guerra, C., Caleiras, E., Muñoz, J., Ortega, S., Drosten, M., Barbacid, M., 2021. KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform. Proc. Natl. Acad. Sci. U. S. A. 118, e2023112118.
Olmeda, D., Cerezo‐Wallis, D., Mucientes, C., Calvo, T.G., Cañón, E., Alonso‐Curbelo, D., Ibarz, N., Muñoz, J., Rodriguez‐Peralto, J.L., Ortiz‐Romero, P., Ortega, S., Soengas, M.S., 2021. Live imaging of neolymphangiogenesis identifies acute antimetastatic roles of dsRNA mimics. EMBO Mol. Med. 13, 1–20.
Amor López, A., Mazariegos, M.S., Capuano, A., Ximénez-Embún, P., Hergueta-Redondo, M., Recio, J.Á., Muñoz, E., Al-Shahrour, F., Muñoz, J., Megías, D., Doliana, R., Spessotto, P., Peinado, H., 2021. Inactivation of emilin-1 by proteolysis and secretion in small extracellular vesicles favors melanoma progression and metastasis. Int. J. Mol. Sci. 22, 7406.
Martinez-Val, A., Lynch, C.J., Calvo, I., Ximénez-Embún, P., Garcia, F., Zarzuela, E., Serrano, M., Munoz, J., 2021. Dissection of two routes to naïve pluripotency using different kinase inhibitors. Nat. Commun. 12, 1863.
García-Silva, S., Benito-Martín, A., Nogués, L., Hernández-Barranco, A., Mazariegos, M.S., Santos, V., Hergueta-Redondo, M., Ximénez-Embún, P., Kataru, R.P., Lopez, A.A., Merino, C., Sánchez-Redondo, S., Graña-Castro, O., Matei, I., Nicolás-Avila, J.Á., Torres-Ruiz, R., Rodríguez-Perales, S., Martínez, L., Pérez-Martínez, M., Mata, G., Szumera-Ciećkiewicz, A., Kalinowska, I., Saltari, A., Martínez-Gómez, J.M., Hogan, S.A., Saragovi, H.U., Ortega, S., Garcia-Martin, C., Boskovic, J., Levesque, M.P., Rutkowski, P., Hidalgo, A., Muñoz, J., Megías, D., Mehrara, B.J., Lyden, D., Peinado, H., 2021. Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism. Nat. Cancer 2, 1387–1405.
de la Calle Arregui, C., Plata-Gómez, A.B., Deleyto-Seldas, N., García, F., Ortega-Molina, A., Abril-Garrido, J., Rodriguez, E., Nemazanyy, I., Tribouillard, L., de Martino, A., Caleiras, E., Campos-Olivas, R., Mulero, F., Laplante, M., Muñoz, J., Pende, M., Sabio, G., Sabatini, D.M., Efeyan, A., 2021. Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling. Nat. Commun. 12, 1–20.
2020
Cash, T.P., Alcalá, S., Rico-Ferreira, M.D.R., Hernández-Encinas, E., García, J., Albarrán, M.I., Valle, S., Muñoz, J., Martínez-González, S., Blanco-Aparicio, C., Pastor, J., Serrano, M., Sainz, B., 2020. Induction of lysosome membrane permeabilization as a therapeutic strategy to target pancreatic cancer stem cells. Cancers (Basel). 12, 1–25.
Cerezo-Wallis, D., Contreras-Alcalde, M., Troulé, K., Catena, X., Mucientes, C., Calvo, T.G., Cañón, E., Tejedo, C., Pennacchi, P.C., Hogan, S., Kölblinger, P., Tejero, H., Chen, A.X., Ibarz, N., Graña-Castro, O., Martinez, L., Muñoz, J., Ortiz-Romero, P., Rodriguez-Peralto, J.L., Gómez-López, G., Al-Shahrour, F., Rabadán, R., Levesque, M.P., Olmeda, D., Soengas, M.S., 2020. Midkine rewires the melanoma microenvironment toward a tolerogenic and immune-resistant state. Nat. Med. 26, 1865–1877.
Eslava-Alcon, S., Extremera-García, M.J., Sanchez-Gomar, I., Beltrán-Camacho, L., Rosal-Vela, A., Muñoz, J., Ibarz, N., Alonso-Piñero, J.A., Rojas-Torres, M., Jiménez-Palomares, M., González-Rovira, A., Conejero, R., Doiz, E., Rodriguez-Piñero, M., Moreno-Luna, R., Durán-Ruiz, M.C., 2020. Atherosclerotic pre-conditioning affects the paracrine role of circulating angiogenic cells ex-vivo. Int. J. Mol. Sci. 21, 1–21.
Montero-Conde, C., Graña-Castro, O., Martín-Serrano, G., Martínez-Montes, Á.M., Zarzuela, E., Muñoz, J., Torres-Perez, R., Pita, G., Cordero-Barreal, A., Leandro-García, L.J., Letón, R., López de Silanes, I., Guadalix, S., Pérez-Barrios, A., Hawkins, F., Guerrero-Álvarez, A., Álvarez-Escolá, C., Regojo-Zapata, R.M., Calsina, B., Remacha, L., Roldán-Romero, J.M., Santos, M., Lanillos, J., Jordá, M., Riesco-Eizaguirre, G., Zafon, C., González-Neira, A., Blasco, M.A., Al-Shahrour, F., Rodríguez-Antona, C., Cascón, A., Robledo, M., 2020. Hsa-miR-139-5p is a prognostic thyroid cancer marker involved in HNRNPF-mediated alternative splicing. Int. J. Cancer 146, 521–530.
Lynch, C.J., Bernad, R., Martínez-Val, A., Shahbazi, M.N., Nóbrega-Pereira, S., Calvo, I., Blanco-Aparicio, C., Tarantino, C., Garreta, E., Richart-Ginés, L., Alcazar, N., Graña-Castro, O., Gómez-Lopez, G., Aksoy, I., Muñoz-Martín, M., Martinez, S., Ortega, S., Prieto, S., Simboeck, E., Camasses, A., Stephan-Otto Attolini, C., Fernandez, A.F., Sierra, M.I., Fraga, M.F., Pastor, J., Fisher, D., Montserrat, N., Savatier, P., Muñoz, J., Zernicka-Goetz, M., Serrano, M., 2020. Global hyperactivation of enhancers stabilizes human and mouse naive pluripotency through inhibition of CDK8/19 Mediator kinases. Nat. Cell Biol. 22, 1223–1238.
Baliñas-Gavira, C., Rodríguez, M.I., Andrades, A., Cuadros, M., Álvarez-Pérez, J.C., Álvarez-Prado, Á.F., de Yébenes, V.G., Sánchez-Hernández, S., Fernández-Vigo, E., Muñoz, J., Martín, F., Ramiro, A.R., Martínez-Climent, J.A., Medina, P.P., 2020. Frequent mutations in the amino-terminal domain of BCL7A impair its tumor suppressor role in DLBCL. Leukemia 34, 2722–2735.
Ma, W., Gil, H.J., Escobedo, N., Benito-Martín, A., Ximénez-Embún, P., Muñoz, J., Peinado, H., Rockson, S.G., Oliver, G., 2020. Platelet factor 4 is a biomarker for lymphatic-promoted disorders. JCI Insight 5.
2019
Borghesan M, Fafián-Labora J, Eleftheriadou O, Carpintero-Fernández P, Paez-Ribes M, Vizcay-Barrena G, Swisa A, Kolodkin-Gal D, Ximénez-Embún P, Lowe R, Martín-Martín B, Peinado H, Muñoz J, Fleck RA, Dor Y, Ben-Porath I, Vossenkamper A, Muñoz-Espin D, O'Loghlen A. Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3. Cell Rep. 2019 Jun 25;27(13):3956-3971 (Pubmed)
García-Silva S, Benito-Martín A, Sánchez-Redondo S, Hernández-Barranco A, Ximénez-Embún P, Nogués L, Mazariegos MS, Brinkmann K, Amor López A, Meyer L, Rodríguez C, García-Martín C, Boskovic J, Letón R, Montero C, Robledo M, Santambrogio L, Sue Brady M, Szumera-Ciećkiewicz A, Kalinowska I, Skog J, Noerholm M, Muñoz J, Ortiz-Romero PL, Ruano Y, Rodríguez-Peralto JL, Rutkowski P, Peinado H. Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF (V600E) mutation. J Exp Med. 2019 May 6;216(5):1061-1070. (Pubmed)
Sayago C, Martinez-Val A, Munoz J. Proteotyping pluripotency with mass spectrometry. Expert Rev Proteomics. 2019 May;16(5):391-400. (Pubmed)
Karras P, Riveiro-Falkenbach E, Cañón E, Tejedo C, Calvo TG, Martínez-Herranz R, Alonso-Curbelo D, Cifdaloz M, Perez-Guijarro E, Gómez-López G, Ximenez-Embun P, Muñoz J, Megias D, Olmeda D, Moscat J, Ortiz-Romero PL, Rodríguez-Peralto JL, Soengas MS. p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors. Cancer Cell. 2019 Jan 14;35(1):46-63. (Pubmed)
2018
Hurtado B, Trakala M, Ximénez-Embún P, El Bakkali A, Partida D, Sanz-Castillo B, Álvarez-Fernández M, Maroto M, Sánchez-Martínez R, Martínez L, Muñoz J, García de Frutos P, Malumbres M. Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeletal dynamics in platelets. J Clin Invest. 2018 Dec 3;128(12):5351-5367. (Pubmed)
Zagorac I, Fernandez-Gaitero S, Penning R, Post H, Bueno MJ, Mouron S, Manso L, Morente MM, Alonso S, Serra V, Muñoz J, Gómez-López G, Lopez-Acosta JF, Jimenez-Renard V, Gris-Oliver A, Al-Shahrour F, Piñeiro-Yañez E, Montoya-Suarez JL, Apala JV, Moreno-Torres A, Colomer R, Dopazo A, Heck AJR, Altelaar M, Quintela-Fandino M. In vivo phosphoproteomics reveals kinase activity profiles that predict treatment outcome in triple-negative breast cancer. Nat Commun. 2018 Aug 29;9(1):3501. (Pubmed)
Segura V, Valero ML, Cantero L, Muñoz J, Zarzuela E,García F, Aloria K, Beaskoetxea J, Arizmendi JM, Navajas R, Paradela A, Díez P, Dégano RM, Fuentes M, Orfao A, Montero AG, Garin-Muga A, Corrales FJ, Pino MMSD. In-Depth Proteomic Characterization of Classical and Non-Classical Monocyte Subsets.Proteomes. 2018 Feb 5;6(1). (Pubmed)
Priego N, Zhu L, Monteiro C, Mulders M, Wasilewski D, Bindeman W, Doglio L, Martínez L, Martínez-Saez E, Ramón Y Cajal S, Megías D, Hernández-Encinas E, Blanco-Aparicio C, Martínez L, Zarzuela E, Muñoz J, Fustero-Torre C, Piñeiro-Yáñez E, Hernández-Laín A, Bertero L, Poli V, Sanchez-Martinez M, Menendez JA, Soffietti R, Bosch-Barrera J, Valiente M. STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis. Nat Med. 2018 Jul;24(7):1024-1035. (Pubmed)
Lynch CJ, Bernad R, Calvo I, Nóbrega-Pereira S, Ruiz S, Ibarz N, Martinez-Val A, Graña-Castro O, Gómez-López G, Andrés-León E, Espinosa Angarica V, Del Sol A, Ortega S, Fernandez-Capetillo O, Rojo E, Munoz J, Serrano M. The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity. Cell Rep. 2018 Jan 9;22(2):396-410 (Pubmed)
2017
Cifdaloz M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J, Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL, Megías D, Valcárcel J, Soengas MS. Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1. Nat Commun. 2017 Dec 21;8(1):2249. (Pubmed)
Rio-Machin A, Gomez-Lopez G, Muñoz J, Garcia F, Maiques-Diaz A, Alvarez S, Salgado RN, Shrestha M, Torres R, Haferlach C, Larrayoz MJ, Calasanz MJ, Fitzgibbon J, Cigudosa JC. The molecular pathogenesis of the NUP98-HOXA9 fusion protein in acute myeloid leukemia. Leukemia. 2017 Jun 20. (Pubmed)
Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez-Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita J, Muñoz J, Falcón-Pérez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo A. mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer. Nature. 2017 Jul 6;547(7661):109-113. (Pubmed)
Olmeda D, Cerezo-Wallis D, Riveiro-Falkenbach E, Pennacchi PC, Contreras-Alcalde M, Ibarz N, Cifdaloz M, Catena X, Calvo TG, Cañón E, Alonso-Curbelo D, Suarez J, Osterloh L, Graña O, Mulero F, Megías D, Cañamero M, Martínez-Torrecuadrada JL, Mondal C, Di Martino J, Lora D, Martinez-Corral I, Bravo-Cordero JJ, Muñoz J, Puig S, Ortiz-Romero P, Rodriguez-Peralto JL, Ortega S, Soengas MS. Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine. Nature. 2017 Jun 28;546(7660):676-680. (Pubmed)
Martinez-Val A, Garcia F, Ximénez-Embún P, Martínez Teresa-Calleja A, Ibarz N, Ruppen I, Munoz J. Urea Artifacts Interfere with Immuno-Purification of Lysine Acetylation. J Proteome Res. 2017 Feb 3;16(2):1061-1068. (Pubmed)
Vialas V, Colomé-Calls N, Abian J, Aloria K, Alvarez-Llamas G, Antúnez O, Arizmendi JM, Azkargorta M, Barceló-Batllori S, Barderas MG, Blanco F, Casal JI, Casas V, de la Torre C, Chicano-Gálvez E, Elortza F, Espadas G, Estanyol JM, Fernandez-Irigoyen J, Fernandez-Puente P, Fidalgo MJ, Fuentes M, Gay M, Gil C, Hainard A, Hernaez ML, Ibarrola N, Kopylov AT, Lario A, Lopez JA, López-Lucendo M, Marcilla M, Marina-Ramírez A, Marko-Varga G, Martín L, Mora MI, Morato-López E, Muñoz J, Odena MA, de Oliveira E, Orera I, Ortea I, Pasquarello C, Ray KB, Rezeli M, Ruppen I, Sabidó E, Del Pino MM, Sancho J, Santamaría E, Vazquez J, Vilaseca M, Vivanco F, Walters JJ, Zgoda VG, Corrales FJ, Canals F, Paradela A. A multicentric study to evaluate the use of relative retention times in targeted proteomics. J Proteomics. 2017 Jan 30;152:138-149. (Pubmed)
2016
Portegijs V, Fielmich LE, Galli M, Schmidt R, Muñoz J, van Mourik T, Akhmanova A, Heck AJ, Boxem M, van den Heuvel S. Multisite Phosphorylation of NuMA-Related LIN-5 Controls Mitotic Spindle Positioning in C. elegans. PLoS Genet. 2016 Oct 6;12(10):e1006291. (Pubmed)
Waaijers S, Muñoz J, Berends C, Ramalho JJ, Goerdayal SS, Low TY, Zoumaro-Djayoon AD, Hoffmann M, Koorman T, Tas RP, Harterink M, Seelk S, Kerver J, Hoogenraad CC, Bossinger O, Tursun B, van den Heuvel S, Heck AJ, Boxem M. A tissue-specific protein purification approach in Caenorhabditis elegans identifies novel interaction partners of DLG-1/Discs large. BMC Biol. 2016 Aug 9;14:66. (Pubmed)
Navarro P, Bueno MJ, Zagorac I, Mondejar T, Sanchez J, Mourón S, Muñoz J, Gómez-López G, Jimenez-Renard V, Mulero F, Chandel NS, Quintela-Fandino M. Targeting Tumor Mitochondrial Metabolism Overcomes Resistance to Antiangiogenics. Cell Rep. 2016 Jun 21;15(12):2705-18. (Pubmed)
Martinez-Val A, Garcia F, Ximénez-Embún P, Ibarz N, Zarzuela E, Ruppen I, Mohammed S, Munoz J. On the Statistical Significance of Compressed Ratios in Isobaric Labeling: A Cross-Platform Comparison. J Proteome Res. 2016 Sep 2;15(9):3029-38. (Pubmed)
Lecona E, Rodriguez-Acebes S, Specks J, Lopez-Contreras AJ, Ruppen I, Murga M, Muñoz J, Mendez J, Fernandez-Capetillo O. USP7 is a SUMO deubiquitinase essential for DNA replication. Nat Struct Mol Biol. 2016 Apr;23(4):270-7. (Pubmed)
2015
Benevento M, Tonge PD, Puri MC, Nagy A, Heck AJ, Munoz J. Fluctuations in histone H4 isoforms during cellular reprogramming monitored by middle-down proteomics. Proteomics. 2015 Sep;15(18):3219-31. (PubMed)
Welling M, Chen HH, Muñoz J, Musheev MU, Kester L, Junker JP, Mischerikow N, Arbab M, Kuijk E, Silberstein L, Kharchenko PV, Geens M, Niehrs C, van de Velde H, van Oudenaarden A, Heck AJ, Geijsen N. DAZL regulates Tet1 translation in murine embryonic stem cells.EMBO Rep. 2015 Jul;16(7):791-802. (PubMed)
Shakiba N, White CA, Lipsitz YY, Yachie-Kinoshita A, Tonge PD, Hussein SM, Puri MC, Elbaz J, Morrissey-Scoot J, Li M, Munoz J, Benevento M, Rogers IM, Hanna JH, Heck AJ, Wollscheid B, Nagy A, Zandstra PW. CD24 tracks divergent pluripotent states in mouse and human cells. Nat Commun. 2015 Jun 16;6:7329. (PubMed)
Wurm S, Zhang J, Guinea-Viniegra J, García F, Muñoz J, Bakiri L, Ezhkova E, Wagner EF. Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2. Genes Dev. 2015 Jan 15;29(2):144-56. (PubMed)
The I, Ruijtenberg S, Bouchet BP, Cristobal A, Prinsen MB, van Mourik T, Koreth J, Xu H, Heck AJ, Akhmanova A, Cuppen E, Boxem M, Muñoz J, van den Heuvel S. Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells. Nat Commun. 2015 Jan 6;6:5906. (PubMed)
2014
Hussein SM, Puri MC, Tonge PD, Benevento M, Corso AJ, Clancy JL, Mosbergen R, Li M, Lee DS, Cloonan N, Wood DL, Munoz J, Middleton R, Korn O, Patel HR, White CA, Shin JY, Gauthier ME, Lê Cao KA, Kim JI, Mar JC, Shakiba N, Ritchie W, Rasko JE, Grimmond SM, Zandstra PW, Wells CA, Preiss T, Seo JS, Heck AJ, Rogers IM, Nagy A. Genome-wide characterization of the routes to pluripotency. Nature. 2014 Dec 11;516(7530):198-206. (PubMed)
Clancy JL, Patel HR, Hussein SM, Tonge PD, Cloonan N, Corso AJ, Li M, Lee DS, Shin JY, Wong JJ, Bailey CG, Benevento M, Munoz J, Chuah A, Wood D, Rasko JE, Heck AJ, Grimmond SM, Rogers IM, Seo JS, Wells CA, Puri MC, Nagy A, Preiss T. Small RNA changes en route to distinct cellular states of induced pluripotency. Nat Commun. 2014 Dec 10;5:5522.(PubMed)
Benevento M, Tonge PD, Puri MC, Hussein SM, Cloonan N, Wood DL, Grimmond SM, Nagy A, Munoz J, Heck AJ. Proteome adaptation in cell reprogramming proceeds via distinct transcriptional networks. Nat Commun. 2014 Dec 10;5:5613. (PubMed)
Chen HH, Welling M, Bloch DB, Muñoz J, Mientjes E, Chen X, Tramp C, Wu J, Yabuuchi A, Chou YF, Buecker C, Krainer A, Willemsen R, Heck AJ, Geijsen N. DAZL limits pluripotency, differentiation, and apoptosis in developing primordial germ cells. Stem Cell Reports. 2014 Nov 11;3(5):892-904 (PubMed)
Muñoz J, Heck AJ. From the human genome to the human proteome. Angew Chem Int Ed Engl. 2014 Oct 6;53(41):10864-6. (PubMed)
Saucedo-Cuevas LP, Ruppen I, Ximénez-Embún P, Domingo S, Gayarre J, Muñoz J, Silva JM, García MJ, Benítez J. CUL4A contributes to the biology of basal-like breast tumors through modulation of cell growth and antitumor immune response.Oncotarget. 2014 Apr 30;5(8):2330-43. (PubMed)
Eguren M, Álvarez-Fernández M, García F, López-Contreras AJ, Fujimitsu K, Yaguchi H, Luque-García JL, Fernández-Capetillo O, Muñoz J, Yamano H, Malumbres M. A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens. Cell Rep. 2014 Feb 27;6(4):670-83. (PubMed)
2013
Di Palma S, Zoumaro-Djayoon A, Peng M, Post H, Preisinger C, Munoz J, Heck AJ. Finding the same needles in the haystack? A comparison of phosphotyrosine peptides enriched by immuno-affinity precipitation and metal-based affinity chromatography. J Proteomics. 2013 Oct 8;91:331-7. (PubMed)
de Cubas AA, Leandro-García LJ, Schiavi F, Mancikova V, Comino-Méndez I, Inglada-Pérez L, Perez-Martinez M, Ibarz N, Ximénez-Embún P, López-Jiménez E, Maliszewska A, Letón R, Gómez Graña A, Bernal C, Alvarez-Escolá C, Rodríguez-Antona C, Opocher G, Muñoz J, Megias D, Cascón A, Robledo M. Integrative analysis of miRNA and mRNA expression profiles in pheochromocytoma and paraganglioma identifies genotype-specific markers and potentially regulated pathways. Endocr Relat Cancer. 2013 Jun 24;20(4):477-93(PubMed)
Berends CW, Muñoz J, Portegijs V, Schmidt R, Grigoriev I, Boxem M, Akhmanova A, Heck AJ, van den Heuvel S. F-actin asymmetry and the endoplasmic reticulum-associated TCC-1 protein contribute to stereotypic spindle movements in the Caenorhabditis elegans embryo. Mol Biol Cell. 2013 Jul;24(14):2201-15(PubMed)
Lopez-Contreras AJ, Ruppen I, Nieto-Soler M, Murga M, Rodriguez-Acebes S, Remeseiro S, Rodrigo-Perez S, Rojas AM, Mendez J, Muñoz J, Fernandez-Capetillo O. A proteomic characterization of factors enriched at nascent DNA molecules. Cell Rep. 2013 Apr 25;3(4):1105-16. (PubMed)
Altelaar AF, Munoz J, Heck AJ. Next-generation proteomics: towards an integrative view of proteome dynamics. Nat Rev Genet. 2013 Jan;14(1):35-48. (PubMed)
2012
Cuello S, Ximénez-Embún P, Ruppen I, Schonthaler HB, Ashman K, Madrid Y, Luque-Garcia JL, Cámara C. Analysis of protein expression in developmental toxicity induced by MeHg in zebrafish. Analyst. 2012 Nov 21;137(22):5302-11. (PubMed)
Vialás V, Perumal P, Gutierrez D, Ximénez-Embún P, Nombela C, Gil C, Chaffin WL. Cell surface shaving of Candida albicans biofilms, hyphae, and yeast form cells. Proteomics. 2012 Aug;12(14):2331-9. (PubMed)
Benevento M, Munoz J. Role of mass spectrometry-based proteomics in the study of cellular reprogramming and induced pluripotent stem cells.Expert Rev Proteomics. 2012 Aug;9(4):379-99. (PubMed)
Muñoz J, Stange DE, Schepers AG, van de Wetering M, Koo BK, Itzkovitz S, Volckmann R, Kung KS, Koster J, Radulescu S, Myant K, Versteeg R, Sansom OJ, van Es JH, Barker N, van Oudenaarden A, Mohammed S, Heck AJ, Clevers H. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent '+4' cell markers. EMBO J. 2012 Jun 12;31(14):3079-91. (PubMed)
Zoumaro-Djayoon AD, Heck AJ, Muñoz J. Targeted analysis of tyrosine phosphorylation by immuno-affinity enrichment of tyrosine phosphorylated peptides prior to mass spectrometric analysis. Methods. 2012 Feb;56(2):268-74. (PubMed)
2011
Muñoz J, Heck AJ. Quantitative proteome and phosphoproteome analysis of human pluripotent stem cells. Methods Mol Biol. 2011;767:297-312. (PubMed)
Munoz J, Low TY, Kok YJ, Chin A, Frese CK, Ding V, Choo A, Heck AJ. The quantitative proteomes of human-induced pluripotent stem cells and embryonic stem cells. Mol Syst Biol. 2011 Nov 22;7:550. (PubMed)
Zoumaro-Djayoon AD, Ding V, Foong LY, Choo A, Heck AJ, Muñoz J. Investigating the role of FGF-2 in stem cell maintenance by global phosphoproteomics profiling. Proteomics. 2011 Oct;11(20):3962-71. (PubMed)
Cappadona S, Muñoz J, Spee WP, Low TY, Mohammed S, van Breukelen B, Heck AJ. Deconvolution of overlapping isotopic clusters improves quantification of stable isotope-labeled peptides. J Proteomics. 2011 Sep 6;74(10):2204-9. (PubMed)
Galli M, Muñoz J, Portegijs V, Boxem M, Grill SW, Heck AJ, van den Heuvel S. aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division. Nat Cell Biol. 2011 Aug 21;13(9):1132-8. (PubMed)
van den Toorn HW, Muñoz J, Mohammed S, Raijmakers R, Heck AJ, van Breukelen B. RockerBox: analysis and filtering of massive proteomics search results. J Proteome Res. 2011 Mar 4;10(3):1420-4. (PubMed)
2009
Santamaría E, Mora MI, Muñoz J, Sánchez-Quiles V, Fernández-Irigoyen J, Prieto J, Corrales FJ. Regulation of stathmin phosphorylation in mouse liver progenitor-29 cells during proteasome inhibition. Proteomics. 2009 Oct;9(19):4495-506. (PubMed)
Muñoz J, Heck AJ. Snapshots of kinase activities. Nat Biotechnol. 2009 Oct;27(10):912-3. (PubMed)
Van Hoof D, Muñoz J, Braam SR, Pinkse MW, Linding R, Heck AJ, Mummery CL, Krijgsveld J. Phosphorylation dynamics during early differentiation of human embryonic stem cells. Cell Stem Cell. 2009 Aug 7;5(2):214-26. (PubMed)
Muñoz J, Heck AJ. Perspectives in stem cell proteomics. Genome Med. 2009 Apr 28;1(4):45. (PubMed)
- 2008
Muñoz J, Fernández-Irigoyen J, Santamaría E, Parbel A, Obeso J, Corrales FJ. Mass spectrometric characterization of mitochondrial complex I NDUFA10 variants. Proteomics. 2008 May;8(9):1898-908. (PubMed)
Fernández-Irigoyen J, Santamaría M, Sánchez-Quiles V, Latasa MU, Santamaría E, Muñoz J, Sánchez Del Pino MM, Valero ML, Prieto J, Avila MA, Corrales FJ. Redox regulation of methylthioadenosine phosphorylase in liver cells: molecular mechanism and functional implications. Biochem J. 2008 Apr 15;411(2):457-65. (PubMed)
Santamaría E, Muñoz J, Fernández-Irigoyen J, Sesma L, Odriozola L, Corrales FJ. Proteomic analysis of liver diseases: molecular mechanisms and biomarker discovery. Mini Rev Med Chem. 2008 Jan;8(1):1-9. (PubMed)
Santamaría E, Muñoz J, Fernández-Irigoyen J, Prieto J, Corrales FJ. Toward the discovery of new biomarkers of hepatocellular carcinoma by proteomics. Liver Int. 2007 Mar;27(2):163-73. (PubMed)
Moreno B, Hevia H, Santamaria M, Sepulcre J, Muñoz J, García-Trevijano ER, Berasain C, Corrales FJ, Avila MA, Villoslada P. Methylthioadenosine reverses brain autoimmune disease. Ann Neurol. 2006 Sep;60(3):323-34. (PubMed)
Santamaría E, Muñoz J, Fernandez-Irigoyen J, Sesma L, Mora MI, Berasain C, Lu SC, Mato JM, Prieto J, Avila MA, Corrales FJ. Molecular profiling of hepatocellular carcinoma in mice with a chronic deficiency of hepatic s-adenosylmethionine: relevance in human liver diseases. J Proteome Res. 2006 Apr;5(4):944-53. (PubMed)
Fernández-Irigoyen J, Santamaría E, Sesma L, Muñoz J, Riezu JI, Caballería J, Lu SC, Prieto J, Mato JM, Avila MA, Corrales FJ. Oxidation of specific methionine and tryptophan residues of apolipoprotein A-I in hepatocarcinogenesis. Proteomics. 2005 Dec;5(18):4964-72. (PubMed)